Equinyl - Chondroitin and Glucosamine: A Perfect Match Many horses face wear and tear from rapid growth, aging, training, and competition. Maintaining the horse's lubrication system is one key to successful care. Science has found that certain nutrients are important building blocks in the horse's natural lubricants and articular cartilage. The most important of these chondroprotective agents are glucosamine and chondroitin sulfate (CS). Together, in liquid Equinyl™, they give targeted support where horses need it most.
Water: The Ultimate Lubricant All the friction generated by all the force of the horse's body is dissipated by one remarkably simple lubricant. The critical squish boundary that prevents bone contact during normal movement is made of water, trapped by the PG complexes of the articular cartilage. Most of the joint fluid itself is water, thickened by hyaluronic acid, which itself is 50% glucosamine. The slippery, compressible surface of cartilage is maintained by the giant water-trapping proteoglycan molecules called proteoglycans (PGs). Nearly half of each PG is made of glucosamine, CS, and their metabolites.
Glucosamine The body must perform a series of reactions to make glucosamine on its own. Scientists believe this is the main rate-limiting step in making GAG lubricants. When additional collagens and lubricants are needed, the rate-limited supply of glucosamine may fail to keep up with demand. Glucosamine's impact on chondroitin sulfate and hyaluronic acid production was first studied over forty years ago. More recently, European scientists compared glucosamine to anti-inflammatory drugs and placebos in over a dozen successful clinical trials. Today, thanks to extensive scientific investigation and wide use around the world, glucosamine enjoys an excellent reputation as a useful connective tissue nutrient. Each fluid ounce serving of Equinyl™ supplies a minimum of 2,500 mg glucosamine HCl.
Chondroitin Sulfates Chondroitin sulfates (CS) are part of the family of natural body lubricants called GAGs. CS are crucial elements of cartilage. In the large PG lubricant molecules of the cartilage matrix, they trap water, help bond collagen fibers, and fight off degradative enzymes. CS are also found in skin, blood vessels, and other tissues. For more than forty years, research in Japan, Europe, and the U.S. has demonstrated the bioactivity of oral CS. Several recent clinical trials, including new equine research, confirm the importance of dietary CS for natural lubricant support. At least 875 mg purified chondroitin sulfates are fed in each one fluid ounce serving of Equinyl™.
What's the difference between glucosamine and chondroitin sulfate? Glucosamine and CS support each other's activity, but it's a case of opposites attract. Glucosamine is a simple molecule, CS is large and complex. Although 85 to 90% of oral glucosamine is absorbed in all species tested, almost all of it goes immediately to the liver, where as much as 80% may be broken down. Only the glucosamine that survives this "first pass" can go on to nourish connective tissues. CS is harder to absorb, and absorbs at different rates by species. Biologists are still exploring the absorption of CS and the many ways it can nourish natural lubricant systems. See our FAQs article for more information.
Bromelain From the heart and stem of the pineapple we harvest bromelain, one of the family of protease nutrients. Also called proteolytic enzymes, these natural compounds are part of the clean up crew that breaks up debris and helps restore fluid balance. Dozens of clinical and sports trials have studied proteases for their impact on eicosanoids, the fatty acids from which the body generates prostaglandins and other inflammatory agents. Bromelain is a robust and flexible proteolytic enzyme. It produces the activity of several enzymes across a wide pH range. Some studies have tested bromelain in skeletal and protein renewal processes.
Zinc, Copper, and Manganese Each of these essential minerals is needed for hundreds of metabolic jobs around the horse. During times of growth, repair, injury and infection, they are in high demand for enzymes that regulate everything from immune cell development to collagen and GAG production. Equinyl™ supplies balanced proportions, to help make sure all systems are go to support optimum natural lubricant nutrition.
Liquid or Alfalfa-Base? Are liquid supplements better? Although some goals in nutrition are best achieved with liquid delivery, there's little or no evidence that most nutrients are better absorbed from liquid supplements. Oxidation and nutrient interactions are a greater threat to stability and potency in water-based formulas. Vitamin C degrades quickly in water, so we use patented Ester-C® in alfalfa-based Equinyl C™ and Equinyl CM™, and in new flax-seed based Equinyl GL™, but not in liquid Equinyl™. All three supplements provide excellent body lubricant support. We recommend you select the one that best fits the way you feed.
Recommended Feeding Pour 2 to 3 fluid ounces over feed for first three to four weeks, then 1 to 2 fluid ounces for maintenance. Equinyl™ is ideal for any feeding program for nutritional support of natural body lubricant activity.
Guaranteed analysis, minimum:
| ||Equinyl™||Equinyl C™||Equinyl CM™||Equinyl GL™|
|Nutrient ||fluid oz||1/2 oz||2/3 oz||1 oz|
|Copper||13 mg||13 mg||13 mg||13 mg|
|Zinc||65 mg||65 mg||65 mg||65 mg|
|Manganese||50 mg||50 mg||50 mg||50 mg|
|Vitamin C||na||1,575 mg||1,575 mg||1,575 mg|
|Glucosamine HCl||2,500 mg||2,500 mg||2,500 mg||7,000 mg|
|Chondroitin sulfates||875 mg||875 mg||875 mg||na|
|Bromelain||550 mg||550 mg||550 mg||na|
|Methylsulfonylmethane||na||na||7,500 mg||7,500 mg|
|Days will last||32||64||128|